郑晓燕

学位:工学博士

部门:制药工程系

职称/职务:副教授/硕士生导师

通信地址:西安市太白北路229号 710069,yl8cc永利

电话/传真:13379025584(H)

E-mail: zy129@nwu.edu.cn


研究方向:

[1] 纳米功能材料

[2] 生物医用材料

[3] 药物的缓控释放、预防医学


教育经历:

2013/09—2016/12,yl8cc永利,应用化学专业,博士研究生,导师:马海霞

2009/03—2011/12,yl8cc永利,化学工程专业,硕士研究生,导师:吕兴强

2001/09—2005/06,yl8cc永利,生物工程专业,本科生


科研与学术工作经历:

2021/09 - 今,yl8cc永利,制药工程专业,副教授

2021/06-2021/08,yl8cc永利,制药工程专业,讲师

2017/09-2021/05,西北大学,生命科学学院,师资博士后,合作导师:陈富林

2005/07-2009/02,西安迈克森新材料有限公司质检科,质检员


科研项目(课题)情况

1)主持项目

[1] 药用多肽高效分离、纯化关键技术,开展药用多肽相分离去除内毒素技术开发。国家重点研发计划国家重点研发计划“药用多肽绿色生物制造关键技术与产业示范”(2021YFC2103900)子课题,2021.12-2025.12,70万元,主持人;

[2] 复合离子杂化仿生人工骨支架的3D打印构筑与骨缺损修复规律探究,国家自然科学基金青年基金,21908179,2020/01-2023/12,26万元,主持人;

[3] 基于杂质离子辅助的室温矿化可控合成羟基磷灰石的关键技术研究,陕西省自然科学基金,2018JQ2052,2018/01-2019/12,3万元,主持人;

[4] 纳米磷灰石的理化特性对3D打印人工骨性能的影响研究,中国博士后科学基金(第63批),2018M633556,2018/03-2019/08,5万元,主持人;

[5] 多离子掺杂纳米羟基磷灰石的可控合成与表面改构研究,陕西省教育厅项目,17JS125,2017/06-2019/12,3万元,主持人;

[6] 富县采油厂采出污水加药配方优化研究,2018/06-2019/12,15.4万元,主持人;

2)参与项目

[1] 国家自然科学基金面上项目,21978236,人参皂苷Rk3靶向PD-L1调节肠道菌群对肝癌的抑制及作用机制研究,2020/01-2023/12,66万元,排2;

[2] 国家自然科学基金面上项目,21878246,人参皂苷Rh4对胰岛β细胞的修复及降糖机理研究,2019/01-2022/12,66万元,排3;

[3] 国家自然科学基金面上项目,21776228,人参皂苷Rg5分子尺度调控胰岛素敏感性改善II型糖尿病糖代谢机制,2018/01-2021/12,64万元,排2;

[4] 国家自然科学基金面上项目,21676215,羟基磷灰石/DNA亚纳米尺度复合材料共组装规律及性质研究,2017/01-2020/12,70万元,排3;

[5] 陕西省科技厅项目,2017SF-201,用于软骨修复的亚纳米HAp/胶原蛋白高强度水凝胶的制备,2017/01-2019/12,12万元,排2。


授权发明专利

[1] 郑晓燕,马海霞,范代娣,惠俊峰,一种具有红色荧光标记的铕掺杂羟基磷灰石单晶纳米棒的制备方法,发明专利授权号:ZL 201510348489.6。(授权日期:2020.10.16)

[2] 郑晓燕,马海霞,范代娣,惠俊峰,一种低温矿化制备亚纳米羟基磷灰石超细针的方法,发明专利授权号:ZL 201510605232.4。(授权日期:2019.10.25)

[3] 郑晓燕,马海霞,范代娣,惠俊峰,韩静,一种柔性超细羟基磷灰石亚纳米线的制备方法,发明专利授权号:ZL 201510605584.X。(授权日期:2017.07.28)

[4] 郑晓燕,范代娣,惠俊峰,朱晨辉,马晓轩,姜西娟,一种新型医用止血凝胶敷料的制备方法,发明专利授权号:ZL201710503854.5。(授权日期:2020.02.18)

[5] 郑晓燕,范代娣,惠俊峰,段志广,李伟娜,姜西娟,一种含沸石止血凝胶敷料的制备方法,发明专利授权号:ZL201710503858.3。(授权日期:2020.04.21)

[6] 衡春宁,郑晓燕,张小勇,范代娣,惠俊峰,一种羟基磷灰石单晶纳米棒的亲水性改性方法,ZL 201510606934.4。(授权日期:2018.01.23)

[7] 范代娣,米钰,郑晓燕,马沛,惠俊峰,一种新型类人胶原蛋白止血敷料,ZL201610073664.X,(授权日期:2018.10.26)。

[8] 范代娣,马沛,郑晓燕,米钰,惠俊峰,一种抗菌性类人胶原蛋白创面医护膜敷料,专利授权号:ZL 2016100736635,(授权日期:2019.01.25)

[9] 惠俊峰,范代娣,米钰,郑晓燕,邓建军,姜西娟,一种分离介质的制备方法,专利授权号:ZL 201710503815.8。(授权日期:2019.11.19)

[10] 惠俊峰,范代娣,米钰,马沛,郑晓燕,姜西娟,一种超多孔水凝胶的制备方法,专利授权号:ZL 201710503785.8。(授权日期:2019.11.19)

[11] 范代娣,惠俊峰,朱晨辉,马晓轩,郑晓燕,姜西娟,一种防渗防粘连多孔止血凝胶敷料的制备方法,专利授权号:ZL 201710503847.5。(授权日期:2020.04.28)

[12] 惠俊峰,范代娣,米钰,马沛,郑晓燕,姜西娟,一种用于组织填充的惰性多孔水凝胶的制备方法,专利授权号:ZL201710503866.8。(授权日期:2020.04.28)

[13] 惠俊峰,贺其雅,范代娣,郑晓燕,陈昱桥,毛淳怡,杨智键,一种多孔骨修复支架材料及其制备方法,专利授权号:ZL201910177807.5。(授权日期:2020.06.02)

[14] 范代娣,朱晨辉,惠俊峰米钰,郑晓燕马沛,雷桓;一种可生物降解的组织工程皮肤支架的制备方法,专利授权号:ZL 201710802649.9。(授权日期:2020.10.30)


发表论文

[1] Zichen Yang, Tianyu Yao, Xiaoyan Zheng*, JunfengHui, Daidi Fan*. Eu3+/Tb3+-doped whitlockitenanocrystals: controllable synthesis, cell imaging, and the degradation process in the bone reconstruction. Nano Research, 2022, 15, 1303–1309.SCI一区, IF:8.920

[2] Jingjing Shao,Xiaoyan Zheng*,Linlin Qu,Hui Zhang,Huifang Yuan,JunfengHui,Yu Mi,Pei Ma,Daidi Fan*, Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in rodent model. Food & Function, 2020, 11, 1245-1257.SCI一区, IF:4.171

[3] Jiaxin Yao,Heng Zhang,Zejun Zhao,Zhixiao Zhu,Jialing Yao,Xiaoyan Zheng*andYong Yang*。Melamine-Assisted Synthesis of Porous V2O3/N-doped Carbon Hollow Nanospheres for Efficient Sodium-Ion Storage,Dalton Transactions, 2021,50:3867-3873.SCI二区, IF:4.108

[4] Huifang Yuan # , Xiaoyan Zheng # , Wan Liu, Hui Zhang, Jingjing Shao, Jiaxin Yao,Chunyi Mao, JunfengHui*, Daidi Fan*, A novel bovine serum albumin and sodiumalginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defectsrepair, Colloids and Surfaces B: Biointerfaces, 2020, 192 (111041): 1-9.SCI二区, IF:4.389

[5] Xiaoyan Zheng, Dong Feng, Liangrong Yang*, JunfengHui,Jiemiao Yu, QiyuMeng,Huizhou Liu*, Daidi Fan*, Mild stir-assisted membrane dispersion for enhancing propionic acid extraction, Chinese Journal of Chemical Engineering. 2019, 27(11): 2666-2674. (SCI三区, IF:2.627)

[6] Xiaoyan Zheng, JunfengHui, Hui Li, Chenhuizhu, Xiufu Hua, Haixia Ma, Daidi Fan, Fabrication of novel biodegradable porous bone scaffolds based on amphiphilic hydroxyapatite nanorods,Materials Science and Engineering C, 2017, 75: 699-705. SCI二区, IF: 5.880

[7] Xiaoyan Zheng, Meiying Liu, JunfengHui, Daidi Fan*, Haixia Ma, Xiaoyong Zhang*, Yaoyu Wang and Yen Wei*,Ln3+-doped hydroxyapatite nanocrystals:controllable synthesis and cell imaging, Physical Chemistry Chemical Physics,2015, 17: 20301-20307. (SCI二区, IF=3.430)

[8] Jianpeng Sun#, Xiaoyan Zheng#, Hui Li,Daidi Fan,Zhanping Song, Haixia Ma,Xiufu Hua*, JunfengHui*, Monodisperse selenium-substituted hydroxyapatite: controllable synthesis and biocompatibility, Materials Science and Engineering C, 2017, 73: 596-602. (SCI二区, IF: 5.880)

[9] Pengjian Wang,JunfengHui, Tingbiao Yuan, Peng Chen, Yue Su, Wenjie Liang, Fulin Chen, Xiaoyan Zheng*, Yuxin Zhao* and Shi Hu*, Ultrafine nanoparticles of W-doped SnO2 fordurable H2S sensors with fast response andrecovery, RSC Advances, 2019, 9: 11046-11053. (SCI三区, IF:3.119)

[10]Pengjian Wang,Tingbiao Yuan, Huifang Yuan, Xiaoyan Zheng*, Hamza Ijaz,JunfengHui, Daidi Fan, Yuxin Zhao* and Shi Hu*,PdO/SnO2 heterostructure for low-temperaturedetection of CO with fast response and recovery, RSC Advances, 2019, 9, 22875-22882. (SCI三区, IF:3.119)

[11]Gaoyu Chen#,Xiaoyan Zheng#,ChongWang,Junfeng Hui,Xuexi Sheng,Xiangxing Xu*,Jianchun Bao,Weijun Xiu,Lihui Yuwen*andDaidi Fan*, A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals, RSC Advances, 2017,7: 56537-56542.(SCI三区, IF: 3.119)

[12]ChunningHeng#, Xiaoyan Zheng#, Meiying Liu, Dazhuang Xu, Hongye Huang,FengjieDeng, JunfengHui*, Xiaoyong Zhang*, Yen Wei*, Fabrication of luminescent hydroxyapatite nanorods throughsurface-initiatedRAFT polymerization: Characterization, biologicalimagingand drug delivery applications, Applied Surface Science, 2016, 386: 269–275. (SCI二区, IF:6.182 )

[13]Ningxia Xu, Jing Xu, Xiaoyan Zheng, and JunfengHui*, Preparation of Injectable Composite Hydrogels by BlendingPoloxamers with Calcium Carbonate-Crosslinked SodiumAlginate,ChemistryOpen, 2020, 9: 451-458.(SCI三区, IF:2.370 )

[14]CongyuKe, Guomin Lu, Yinglin Wei, Wujuan Sun, JunfengHui, Xiaoyan Zheng,Qunzheng Zhang, Xunli Zhang*,Biodegradation of crude oil by Chelatococcusdaeguensis HB-4 and itspotential for microbial enhanced oil recovery (MEOR) in heavy oil reservoirs, Bioresource Technology, 2019, 287: 121442.(SCI一区, IF:7.539)

[15]ChunningHeng,Xin Zhou,Xiaoyan Zheng,Meiying Liu,Yuanqing Wen,Hongye Huang,Daidi Fan,JunfengHui*,Xiaoyong Zhang*,Yen Wei*. Surface grafting of rare-earth ions doped hydroxyapatite nanorods (HAp:Ln(Eu/Tb)) with hydrophilic copolymers based on ligand exchange reaction: Biological imaging and cancer treatment, Materials Science & Engineering C, 2018, 556-563. (SCI二区, IF: 5.880)

[16]CongyuKe, Wujuan Sun*, Yongbin Li, JunfengHui, Guomin Lu, Xiaoyan Zheng, Qunzheng Zhang, Xunli Zhang*. Polymer-Assisted Microbial-Enhanced Oil Recovery. Energy & Fuels, 2018, 32: 5885-5892. (SCI二区, IF: 3.421)

[17]ChunningHeng, Meiying Liu, Pengfei Wang, Ke Wang, Xiaoyan Zheng, Daidi Fan, JunfengHui*, Xiaoyong Zhang*, Yen Wei*. Preparation of Silica Nanoparticles based Multifuctional Therapeutic Systems via One-step Mussel Inspired Modification,Chemical Engineering Journal, 2016, 296: 268-276. (SCI一区, IF: 10.652 )

[18]ChunningHeng, Meiying Liu, Ke Wang, Xiaoyan Zheng, Hongye Huang, Fengjie Deng, JunfengHui*, Xiaoyong Zhang*, Yen Wei*. Fabrication of silica nanoparticle based polymer nanocomposites via a combination of mussel inspired chemistry and SET-LRP, RSC Advances2015, 5, 91308–91314. (SCI三区, IF=3.119)